منابع مشابه
Biological activities of xanthatin from Xanthium strumarium leaves.
The objective of the present work was to evaluate the biological activities of the major bioactive compound, xanthatin, and other compounds from Xanthium strumarium (Asteraceae) leaves. Inhibition of bloodstream forms of Trypanosoma brucei brucei and leukaemia HL-60 cell proliferation was assessed using resazurin as a vital stain. Xanthatin was found to be the major and most active compound aga...
متن کامل[Acute toxicity of Xanthium spinosum leaves in BALB/C mice].
The leaves of the Xanthium spinosum plant have been used culturally in Paraguay for their medicinal properties. Acute toxicity of mature leaf extract was evaluated. For the study, 35 Balb/c mice were selected and allocated into 7 groups, 6 test groups and 1 control group. The extract was prepared in concentrations of 6% and 9% (g/dL). The 6% concentration was administrated to 3 test groups and ...
متن کاملXanthanolides of Xanthium italicum Moretti and their biological activity.
Seven xanthanolides were identified in the extract of X. italicum leaves. Antibacterial and cytotoxic activities were found for the total extract and its major constituents xanthinin and xanthatin.
متن کاملXanthanolides with antitumour activity from Xanthium italicum.
Bioassay-guided fractionation of a CHCl3 extract of the leaves of Xanthium italicum Moretti led to the isolation of four xanthanolides: xanthatin (1), 4-epixanthanol (2), 4-epi-isoxanthanol (3), and 2-hydroxyxanthinosin (4). Their structures were determined by means of 1D and 2D NMR spectroscopy, including 1H-1H COSY, NOESY, HSQC and HMBC experiments, which resulted in complete and unambiguous ...
متن کاملConcerted Suppression of STAT3 and GSK3β Is Involved in Growth Inhibition of Non-Small Cell Lung Cancer by Xanthatin
Xanthatin, a sesquiterpene lactone purified from Xanthium strumarium L., possesses prominent anticancer activity. We found that disruption of GSK3β activity was essential for xanthatin to exert its anticancer properties in non-small cell lung cancer (NSCLC), concurrent with preferable suppression of constitutive activation of STAT3. Interestingly, inactivation of the two signals are two mutuall...
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ژورنال
عنوان ژورنال: Chemistry of Natural Compounds
سال: 1973
ISSN: 0009-3130,1573-8388
DOI: 10.1007/bf00568655